In Croatia Football Federation-HNS, Talajić is regarded as the prodigy of the one of the Most successful Croatian managers in history, Tomislav Ivić.

As a junior player for FK Sarajevo, Dragan Talajić broke the record of the great Yugoslav goalkeeper Slobodan Janjuš by having received only one goal in the whole season.

After a short spell with NK Orijent in Croatia's Prva HNL, from 1997 to the end of his career Talajić played for Tanjong Pagar United FC in Singapore's S-League.

He led his team to a victory in AFC Cup in Yemen against Al-Ahli Sana'a', drew both home and away against Al-Karmah from Syria, then drew in Oman against Saham and won against Saham in Jordan and qualified to the next round of the AFC Cup, thanks to a win in Jordan against Al-Ahli Sana'a by 6–1.

On 13 August 2010, Talajić won the Jordan Super Cup against Al-Wahdat's bitter rival Al-Faisaly.

FC Nasaf Qarshi had to their advantage the home stadium and fans which led to a hell of an atmosphere for Talajić's team.

On 18 December, Dragan Talajić won the Kuwait Federation Cup beating in the finals Kazma with the result 4–3, in the 50th minute the score was 0–3 in favor of Kazma SC, but Talajić brought in two substitutes and changed the course of the game making the Kuwait Federation Cup finals 2011 more than spectacular.

During his time with Ittihad Kalba he had to face many big defeats from the giants of UAE Arabian Gulf League.

Dragan was in charge of Omani giant Dhofar who won Oman Professional League record 9 times.

On 30 July Talajić led Muangthong United to a 1–1 draw against La Liga side UD Almeria of Spain.

On 18 December 2017, Talajić was appointed as the head coach of Henan Jianye of the Chinese Super League.

[6] Dragan Talajic parted company with Henan due to the club not being able to follow his attacking philosophy.

On 10 February 2022, Talajić took Al Khaldiya's side to the King of Bahrain Cup 2022 Final for the first time in the club's history.

In February 2024, he became the head coach of the national team, and secured his first title in the 26th Arabian Gulf Cup.