Twenty years prior to the story's beginning, an asteroid headed for Earth destroys Pluto.

After witnessing what looks like a murder by a strange creature, Jin Kamishina, a lonely 18-year-old boy who lost his family in a shuttle accident two years ago, gets involved with the ISDA and their efforts to battle the dragons from Thanatos.

As they delve deeper into the mysteries of the dragons, they encounter new friends and enemies, and also develop a closer relationship.

In fact, Manabu Ono expected that the series would continue being developed on, even after it begins broadcast in October 2007.

[6] Directed by Manabu Ono and co-produced by Gonzo and Nihon Ad Systems (NAS), Dragonaut: The Resonance was broadcast for 25 episodes on TV Tokyo from October 4, 2007, to March 27, 2008.

The opening theme, "perfect blue", is performed, composed, and written by the J-pop group Jazzin' Park.

The Dragonaut Station ISDA Information Agency [ja] centered around three voice actors from the anime answering e-mail questions about the series.

Junichi Suwabe, Takuma Takewaka, Daisuke Ono, Eiji Maruyama, who voices Gio, Raina Cromwell, Jin Kamishina, and Amadeus, respectively, were guests during separate sessions.