Following his death, she brings her daughter, Brianna, to the home of the Randalls' old friend, Reverend Reginald Wakefield.
There, Claire hopes the Reverend's adopted son, Roger, can help her discover what happened to the men of Lallybroch after the Battle of Culloden.
Roger, using his Oxford credentials to obtain information, finds proof that the men of Lallybroch returned home safely.
Brianna angrily denies her mother's story, but Roger is fascinated, and Claire recounts her time after the events of Outlander.
At the end of Outlander, Claire has convinced Jamie to stop the Jacobite rising and the subsequent slaughter.
Back in Scotland with Fergus, they settle into farm life at his home at Lallybroch with Jamie's sister Jenny and her family.
Thinking Claire a prisoner, Grey tries to "save" her, whereupon Jamie breaks the boy's arm but spares his life.
After a skirmish and a night of hiding in a church with Jamie, Dougal MacKenzie and his men, Claire is taken by the English who think she is a hostage.
As the disastrous Battle of Culloden approaches, Jamie and Claire discuss assassinating Charles Stuart, but decide against it.
Claire admits to Roger that while hiding in the caves of the Highlands, plotting Jamie's escape from prison (as told in Outlander), Dougal had delivered a message from Geillis that read: "I do not know if it is possible, but I think so" and the numbers 1,9,6 and 8.
Publishers Weekly called Dragonfly in Amber an "immensely long, compulsively readable sequel to Outlander", and noted that by "portraying life in court and hut and on the battlefield through the eyes of a strong-minded, modern participant, Gabaldon offers a fresh and offbeat historical view, framed by an intriguing contemporary issue of Claire's daughter's paternity.