Drefong is a bay horse sired by three-time Eclipse Award winner Gio Ponti, who was best known as a route runner on the turf, but also finished second to Zenyatta in the Breeders' Cup Classic.

[2] His dam Eltimaas is an unraced daughter of Ghostzapper, who won races such as the Met Mile, Woodward, and Breeders' Cup Classic.

Drefong is trained by Hall of Famer Bob Baffert, who helped pick out the colt at the sales based on his excellent conformation.

[2][4] Drefong began his two-year-old-season on October 24, 2015, in a Maiden Special Weight at Santa Anita Park at a distance of 5+1⁄2 furlongs.

He lost ground when he missed the start, made an "eye-catching" move to gain position, but then ducked in at the sixteenth pole fell back to finish fifth.

[5] To start off his sophomore season, Drefong ran in a six-furlong allowance optional claimer at Santa Anita on May 30, 2016, against older horses.

[7] Drefong stepped up to Grade I company in the King's Bishop Stakes at Saratoga on August 27 where his main rivals in a field of twelve were horses that had qualified for the Kentucky Derby, Mohaymen and Tom's Ready.

Starting from the outside post position, Drefong was urged by jockey Mike Smith to the lead, then moved over to the rail and slowed down somewhat to complete the first quarter of a mile in 23.11 seconds.

Mind Your Biscuits closed rapidly to finish third and was eventually promoted to second after a positive drug test disqualified Masochistic.

Now riderless, Drefong attempted to take the lead and then forced the other frontrunners, Roy H and Moe Candy, very wide at the top of the stretch.

[16] Drefong trained up to the Breeders' Cup Sprint, held on November 4 at Del Mar – the same track as his disastrous run in the Bing Crosby.

Geoglyph would go on to win the 2022 Satsuki Shō, the Japanese equivalent of the 2,000 Guineas, to give Drefong his first Grade 1 victory as a sire.