Drepana (Ancient Greek: Δρέπανα) was an Elymian, Carthaginian, and Roman port in antiquity on the western coast of Sicily.

Drepana received its name from drépanon (δρέπανον), the Greek word for "sickle", because of the curving shape of its harbour.

The town, 40 km (25 mi) north of Lilybaeum, had been fortified by the Carthaginians, who resettled part of the population to Eryx.

The naval battle of Drepanum took place in 249 BC and was a major victory for Carthage against the Roman Republic in the First Punic War.

After the Battle of the Aegates and Carthage's loss of the war, the town was ceded to Roman control in 241 BC.