Drepana (Ancient Greek: Δρέπανα) was an Elymian, Carthaginian, and Roman port in antiquity on the western coast of Sicily.

Drepana received its name from drépanon (δρέπανον), the Greek word for "sickle", because of the curving shape of its harbour.

The town, 40 km (25 mi) north of Lilybaeum, had been fortified by the Carthaginians, who resettled part of the population to Eryx.

[1] Carthage seized control of the city in 260 BC, subsequently making it an important naval base.

The naval battle of Drepanum took place in 249 BC and was a major victory for Carthage against the Roman Republic in the First Punic War.