In the 2002 season, Weatherford had his most prolific stats, leading the state in passing touchdowns (ahead of future FSU backup Xavier Lee).

His season ended when they lost to eventual state champion Palm Bay High School, which featured future NFL players Reggie Nelson and Joe Cohen.

Drew Weatherford played his final game in a shootout with Lakeland Lake Gibson High School, losing to the Braves (who were led by USF's eventual star quarterback Matt Grothe), 44–35.

After the career of Wyatt Sexton was cut short by Lyme disease, Weatherford won the starting job over fellow redshirt freshman Xavier Lee during fall practice.

Weatherford missed the Maryland game on October 28, 2006, due to injury, which gave Xavier Lee his shot at the starting job, escalating the quarterback controversy which had been hotly debated all season.

He was expected to be the starter headed into fall camp, but he faced fierce competition from redshirt sophomores D'Vontrey Richardson and Christian Ponder.

On August 3, after two and half scrimmages, Jimbo Fisher, Florida State's quarterbacks coach and offensive coordinator, announced that Christian Ponder would start the Seminoles' game against Western Carolina on September 6.

Weatherford was moved down to third string on the depth chart and played in only one series late in the fourth quarter during FSU's 69–0 blowout of Western Carolina.

[citation needed] Weatherford participated in an open tryout on August 22 for the Orlando Tuskers of the newly formed United Football League.