Drilliola loprestiana is a species of sea snail, a marine gastropod mollusk in the family Borsoniidae.

They illustrated as "holotype Drilliola loprestiana (Calcara, 1841), MAL-1930, photo courtesy of Museo di Zoologia 'P.

[3] The shell has a fusiform shape up to 7 mm high, with elevated spire and body whorl less than half the total height.

The protoconch is proportionally very large, with 4–5 convex whorls and a sculpture of axial riblets and a marked suprasutural keel.

The outer lip is simple, with a deep U-shaped sinus situated next to the suture, then with convex profile in lateral view.