Trisumje was born into the Dro clan, an important Tibetan family based in Kokonor (modern-day Qinghai).
During this period, the Tibetan empire stretched as far west as Samarkand and Kabul and was coming into conflict with the Arabs of western Asia.
During the next fifteen years, Trisumje led an army to conquer a large area of Central Asia, culminating in the successful invasion of the Uyghur Khaganate in 815 AD.
Trisumje led 150,000 troops to attack the Chinese city of Yanzhou, but was forced to retreat after 27 days due to strong resistance.
Three stone monuments carved to commemorate the event list Trisumje as the second highest ministerial witness.