Drôme (French pronunciation: [dʁom] ⓘ; Occitan: Droma; Arpitan: Drôma) is the southernmost department in the Auvergne-Rhône-Alpes region of Southeastern France.

Saint-Vallier in Drôme was the birthplace of one of France's most famous courtesans, the noble-born Diane de Poitiers (1499–1566), long-term mistress of King Henri II (1519–1559).

The original Drôme department contained the exclave of Orange, which was also part of the former province of Dauphiné.

In 1792, following the annexation of Comtat Venaissin, Drôme acquired the newly created district of Carpentras while Orange was ceded to Bouches du Rhône.

In 1793, the district of Carpentras was ceded to the newly formed department of Vaucluse, giving the Drôme its modern-day borders.

Drôme surrounds an exclave of the Vaucluse department, the Canton of Valréas (Enclave des Papes).

The commune of Montfroc forms a small salient which was surrounded by the department of Alpes-de-Haute-Provence, which is similar to the small salients of Newmarket in Suffolk, Dieveniškės in Lithuania, Bogatynia in Poland, West Bengal and Sikkim in India, and the Wakhan Corridor in Afghanistan.

Saint-Donat-sur-l'Herbasse has a moderate temperature of 3 °C in January and 21 °C in July due to the Lyonnic climate, where more precipitation falls in summer than winter.

The most southern part of the department clearly exhibits a Méso-Mediterranean climate with the reinforcement of the mistral and a hotter summer due to the rarity of storms.