With the Odd Fellows Mansion on Bredgade and the central pavilions of the east fringe of the castle garden located at each their end, the street has axial qualities.

These are accentuated by the Dronningegården Estate, a Functionalist housing complex from the 1940s, which forms an urban space around the intersection with Adelgade.

Dronningens Tværgade originates in the 1649 plan for New Copenhagen, the large area which was included in the fortified city when the old East Rampart along present day Gothersgade was decommissioned and a new one was built in a more northerly direction.

According to the plan, the streets in the area were to be named after Danish territorial possessions, royalty and the upper classes.

[3] The Dronningegården Estate, which was designed by Kay Fisker and built from 1943 to 1958, defines a distinctive urban space along the street.