After the release of their debut album, Sinner (2001), original vocalist Dave Williams was found dead on August 14, 2002,[2] from heart disease.

[2] Jasen Moreno was announced as McCombs' replacement in 2012, and the band has recorded three albums with him: Resilience (2013), Hellelujah (2016) and Strike a Nerve (2022).

[5] A number of songs from the album were featured at various WWE events that year, and three tracks would be included on the soundtrack for the Funimation dub of Dragon Ball Z: Cooler's Revenge in early 2002.

The band initially wanted McCombs to join Drowning Pool as the replacement of Dave Williams, nearly two years prior.

Two songs on the album were produced by Funny Farm Records, owned by Mötley Crüe bassist Nikki Sixx and former Beautiful Creatures guitarist DJ Ashba.

[21] On March 3, 2009, the band released a live album, Loudest Common Denominator, which featured acoustic versions of "Shame" and "37 Stitches" from Full Circle.

Pierce and Mike Luce announced a new project with former Nonpoint members Zach Broderick and Ken McMillan titled Voodoo Corps.

[27] On August 14, the 10th anniversary of Dave Williams' death, the band released a song in tribute of him, their first with Moreno titled "In Memory Of...".

[30] On September 10, the band announced that they would celebrate the thirteenth anniversary of Sinner with a U.S. tour starting from October 22, in which they plan to dig deep into the songs from their debut album.

[33] On October 13, it was announced the band's sixth album titled Hellelujah would be released January 22, 2016, via eOne Music with producer Jason Suecof;[34] the date was later postponed to February 5.

[35] On May 17, 2016, the band announced that they would be taking part in the Make America Rock Again super tour on select dates throughout the summer and fall 2016.

The tour featured other artists who had success throughout the 2000s, including Trapt, Saliva, Saving Abel, Crazy Town, 12 Stones and Tantric, Fuel, Puddle Of Mudd and P.O.D.

On February 16, 2022, Drowning Pool announced Strike a Nerve as the name of their seventh studio album, which had already been completed by early 2020, but the COVID-19 pandemic meant that its release date was then postponed.

[39] Prior to the release of Strike a Nerve, Drowning Pool embarked on the North American tour Brothers in Arms with Ill Niño and (hed)p.e.

[42] On March 16, 2023, Drowning Pool announced that Ryan McCombs (while continuing his vocal duties with SOiL) had rejoined the band after a 12-year absence.

[48] Shortly after the shooting, the band made a statement addressing the link: "We were devastated this weekend to learn of the tragic events that occurred in Arizona and that our music has been misinterpreted.

The band's influences include Metallica, Guns N' Roses, Anthrax, Testament, Slipknot, Alice in Chains, SOiL, Opeth, Nirvana, Soundgarden, Black Sabbath, Slayer, AC/DC, Led Zeppelin, Judas Priest, Iron Maiden, Mötley Crüe, the Beatles, Pantera, Sepultura and Suicidal Tendencies.