The station was opened on 13 April 1846 by the Ashton, Stalybridge & Liverpool Junction Railway.

The station was closed by British Railways on 7 October 1968.

Droylsden railway station had 4 platforms, two on the original Manchester to Stalybridge line and two on the later London and North Western Railway line to Denton.

[1] The Littlemoss Aqueduct carried the Hollinwood Branch of the Ashton Canal over the railway just west of the station.

This article on a railway station in Greater Manchester is a stub.