This research was fueled by revenues from the sale of morphine, an alkaloid found in opium, first identified by the German chemist and pharmacist Friedrich Sertürner in 1804[3] and patented by Merck soon afterward.
German pharmaceutical companies' work with morphine and its derivatives found particular success in using them as pain relievers and cough suppressants, with Bayer eventually recognizing the potency of heroin, which was legal in Germany at the time (and until the 1950s, before which it was banned only in Asia and the United States).
[citation needed] The German populace's experience during and after the First World War inspired the Weimar and Nazi governments to adopt an attitude of tolerance toward the use of drugs to relieve pain, increase performance, and avoid withdrawal.
[6] Nazi military doctor Otto Friedrich Ranke tested the drug on 90 university students to study its effects, which led him to conclude that Pervitin could help Germany win the war.
At first, high-ranking officials encouraged its use as a means of relaxation and a crude method of mitigating the psychological effects of combat, in the latter case through what later scientific developments would describe as blocking the consolidation of traumatic memories.
After the Fall of France, however, Wehrmacht commanders observed that their soldiers' behavior was deteriorating, with "fights, accidents, mistreatment of subordinates, violence against superior officers and "crimes involving unnatural sexual acts" becoming more frequent.
[7] The Commander-in-Chief of the German military, General Walther von Brauchitsch, concluded that his troops were committing "most serious infractions" of morality and discipline, and that the culprit was alcohol abuse.
Ohler claims that when Hitler's drug supplies ran out by the end of the war, he suffered severe withdrawal from serotonin and dopamine, paranoia, psychosis, rotting teeth, extreme shaking, kidney failure and delusion.
Hitler's tremors late in life have been popularly attributed to Parkinson's Disease, perhaps induced early by his drug use, whereas Ohler argues amphetamines to have been entirely responsible.