He started his senior career at Meteor in 1984, before moving to Montáže Prag and subsequently FC Jílové.

Although Uhrin first managed RH Strašnice in 1990, his first real major team in 2000, when he co-coached Slavia Prague.

Although Poli finished second at the end of the 2010–11 Liga I season and was supposed to play in the 2011–12 UEFA Champions League, it was relegated to the Liga II because of accumulated debt and Dušan Uhrin left Poli on 27 July 2011.

[4] He resigned on 6 December 2013,[5] and will return to the Czech Republic to manage FC Viktoria Plzeň in 2014.

[6] On 26 February 2024, Uhrin was appointed as manager of Slovak club Zlaté Moravce.