The DuPont Building, occupying the entire block bound by 10th, 11th, Orange, and Market streets, was one of the first high-rises in Wilmington, Delaware, United States.

[6] Under pressure from activist shareholders, the company first leased the building's DuPont Playhouse in January 2015 to the Grand Opera House, which renamed it The Playhouse on Rodney Square.

[7] The entire structure and the hotel business were then sold to Wilmington-based developer Buccini/Pollin in January 2018.

The new owners have leased the building's office space back to Chemours, will continue to lease The Playhouse to The Grand Opera House, and have promised to keep the hotel operating.

[8] Hotel du Pont was where Joe Biden announced his candidacy for the 1972 United States Senate election in Delaware.