Superficially, it resembled Playhouse 90 and other anthologies, but DuPont Show of the Month focused less on contemporary dramas and more on adaptations of literary classics, including Oliver Twist, The Prince and the Pauper, Billy Budd, The Prisoner of Zenda, A Tale of Two Cities and The Count of Monte Cristo.

DuPont Show of the Month was the first anthology series to stage a television dramatization of Thornton Wilder's only novel, The Bridge of San Luis Rey.

Julie Andrews,[1] Rex Harrison, Carol Channing,[1] John Gielgud, Gracie Fields, Richard Burton, Lee J. Cobb, Colleen Dewhurst, Eli Wallach, Hurd Hatfield, Judith Anderson, Hume Cronyn, Maureen O'Hara, Michael Rennie, Suzanne Storrs, Farley Granger, Fritz Weaver, and George C. Scott made appearances.

With its stage cast, DuPont Show of the Month telecast the 1958 Old Vic production of William Shakespeare's Hamlet immediately following its brief run on Broadway.

Carol Lynley had the lead role of Judy Graves with Don Ameche and Joan Bennett as her parents and Susanne Sidney as Fuffy Adams.