Jean Baptiste Point DuSable High School is a public 4–year high school campus in the Bronzeville neighborhood on the South Side of Chicago, Illinois, United States, owned by Chicago Public Schools and named after Chicago's first permanent non-native settler, Jean Baptiste Point Du Sable.

[6] The DuSable Leadership Academy was also housed at the location until it closed after the 2015–16 school year.

[8] In 1929, the Chicago Board of Education voted to construct a new school building at East 49th Street and South Wabash Avenue due to the overcrowding conditions at Wendell Phillips Academy High School.

Because of this, in 2003, Chicago Public Schools decided to phase out DuSable: the history of poor academic performance was also a factor.

The school is named for Daniel Hale Williams, an African-American doctor who performed the first successful open heart surgery.

[22][23][24][25] The school once held an inner sanctuary that had many different animals, including peacocks, a goat, snakes, pigeons, chickens, and various other species.

Emiel Hamberlin, the schools' biology teacher and sanctuary was featured in the March 1977 issue of Ebony magazine.

[27] In 1995, with funding from NASA, DuSable became the first public high school in Chicago to be connected to the Internet.

[30] In October 1959, two female students were sexually assaulted by a male mail carrier in the school.

[33] On October 13, 1987, 15–year-old freshmen Dartagnan Young was shot to death in a gang–related shooting in the hallway on the school's third floor shortly after 8 a.m. by 16–year-old sophomore Larry Sims.

[36][37] DuSable competes in the Chicago Public League (CPL) and is a member of the Illinois High School Association (IHSA).