Du Zhenyu started his career in 2001 with Changchun Yatai, where in his first season he made eighteen appearances, scoring five goals.
[3] The 2007 league season was to prove the most successful for Du Zhenyu, as he played a significant part in the title-winning Changchun Yatai team, subsequently winning the Footballer of the Year award in the process.
[6] At the beginning of the 2012 Chinese Super League season, Du lost favour within the team to Liu Weidong, which soon saw him decide to move to Tianjin Teda on loan, where he made his debut on July 14, 2012, against Qingdao Jonoon in a league game that ended in a 0-0 draw.
[9] Despite his suspension carrying on to the following season, Tianjin decided to make his move permanent before the start of the 2013 Chinese Super League.
At the age of 32, he decided to return to his former club, Changchun Yatai, and signed a two-year deal with the side.