The shooting occurred when the car carrying Shakur was stopped at a red light at East Flamingo Road and Koval Lane.

[4][5] Tupac Shakur attended the Bruce Seldon vs. Mike Tyson boxing match with Marion "Suge" Knight, the head of Death Row Records, at the MGM Grand in Las Vegas, Nevada.

He disclosed to his girlfriend Kidada Jones his involvement in the Anderson fight, previously having promised to return to her after entering the MGM Grand and having her stay in a vehicle.

[11][12] At 11:10 p.m., while they were stopped at a red light at the intersection of East Flamingo Road and Koval Lane in front of the Maxim Hotel, a vehicle occupied by two women pulled up on their left side.

[16] Yaki Kadafi was riding in the car behind Shakur with bodyguards at the time of the shooting and, along with members of the Death Row entourage, refused to cooperate with police.

[17] Despite Knight's injuries and his vehicle having a flat tire, he was able to drive Shakur and himself a mile from the site to Las Vegas Boulevard and Harmon Avenue.

At the hospital, Shakur was heavily sedated, was placed on life support machines, and was ultimately put under a medically-induced coma after repeatedly trying to get out of bed.

[21] While in the critical care unit on the afternoon of Friday, September 13, 1996, Shakur died of respiratory failure that led to cardiac arrest after the removal of his right lung.

Philips reported that "the shooting was carried out by a Compton gang called the South Side Crips to avenge the beating of one of its members by Shakur a few hours earlier.

Philips's article also implicated East Coast rappers, including The Notorious B.I.G., Tupac's rival at the time, and several New York City criminals.

Haaretz, an Israeli newspaper, reported in 2011 that the FBI released documents as a result of a Freedom of Information Act request, revealing its investigation of the Jewish Defense League for extorting protection money from Shakur and other rappers after making death threats against them.

[26][27] In 2017, Knight claimed he might have been the target of the attack that killed Shakur, arguing that it was a hit on him as a staged coup to seize control of Death Row Records.

The year following the shooting, Knight stated during an ABC Primetime Live interview that he did not know who had shot Shakur but would never tell officers if he did.

Kadafi left Las Vegas days after Shakur's death, traveling to Atlanta and Los Angeles before settling in New Jersey, where his relatives lived.

In that time, Compton investigators assembled mug shots of several gang members, which included Anderson, and hand-delivered them to Las Vegas.

Officers did not try to locate Kadafi, who was fatally shot in a housing project in Irvington, New Jersey, in November 1996, two months after Shakur's shooting.

[30] Mean and Alexander told the Times in early 1997 that they had never been asked by Las Vegas police to view photos of possible suspects in the case, despite having observed the shooting and having seen the men in the car from which the shots were fired.

In an interview with Alexander conducted by Las Vegas police on March 19, 1997, he was shown a series of eight photo lineups, but was unable to identify any suspects from them.

[31] In the USA Network documentary Unsolved, broadcast in 2018, Duane "Keefe D" Davis, a Crips gang leader in California and Anderson's uncle, claimed to have been in the car, specifically in the front passenger seat, with Tupac's murderer when the shots were fired.

[35] According to Radar Online, Keefe D stated that after waiting near Club 662, they went to a Liquor Barn store and they then proceeded to make their way to The Carriage House hotel.

[41] On November 7, 2023, Judge Carli Kierny for the Clark County District Court scheduled for Davis' trial to begin on June 3, 2024.

[46][45] During the grand jury hearing, a South Side Compton Crips gang affiliate testified that it was DeAndrae Smith who was the shooter, not Orlando Anderson.

[47]In October 2024, reports surfaced that the family of Tupac Shakur had hired an investigator to see if the murder could be linked to Sean "Diddy" Combs, the founder of Bad Boy Records.

[48] Meanwhile, an individual lawsuit alleged that Diddy raped a woman in 2018 with a remote control after she made a comment suggesting that Combs was involved in the murder of Shakur.