It existed during the Late Middle Ages and the early modern period, from 1471 to 1520, as well as 1695 to 1701.

The state was formed in 1471, when duke Henry IV, had united the duchies of Mecklenburg-Stargard and Mecklenburg-Schwerin.

[1] The state existed until 7 May 1520, when it was partitioned into the duchies of Mecklenburg-Güstrow and Mecklenburg-Schwerin.

[2][3] It was again reestablished in 1695, with the unification of Mecklenburg-Güstrow and Mecklenburg-Schwerin.

In 1701, it was partitioned into the duchies of Mecklenburg-Schwerin and Mecklenburg-Strelitz.