Duddeston opened in 1837 as Vauxhall, the temporary Birmingham terminus of the Grand Junction Railway from Warrington.

An extract from an 1859 railway inspector's report into a minor collision reveals something of how the station was operated:[2] There are sidings on both sides of the main line, and the station being on a curve, and the view interrupted by buildings, it is necessary to have a series of signalmen at short intervals for the protection of the switches and crossings connected with the main line

One of these signalmen (for the protection of the down line), when he had any shunting to do, had to warn a signalman on his right by turning on a disc signal; and he had also to work the arm of a semaphore signal on the Birmingham side of the station to stop all down trains on the main line.The station was rebuilt and re-opened to passengers in 1869 under the LNWR and was renamed Vauxhall and Duddeston in 1889.

The line through the station, to Walsall via Perry Barr, was electrified in 1966 as part of the London Midland Region's electrification programme.

[3] The actual energization of the line from Coventry to Walsall through Perry Barr took place on 15 August 1966.