Dudleya guadalupensis is a very rare species of succulent perennial plant in the family Crassulaceae commonly known as the Guadalupe liveforever.

[1] A densely-leaved species of Dudleya, with the outer foliage folding over the center, giving the rosettes a rounded appearance.

The leaves are shaped oblong to oblanceolate, the leaf margins rounded, and the tip apiculate to acuminate.

[2][4] The plant is said to bear a superficial resemblance to Dudleya linearis, native to San Benito Island.

[5] No other expeditions found or mentioned Dudleya until 1948,[4] when Reid Moran and George Lindsay visited the island.

[5] The second population of Dudleya was discovered by Moran and Lindsay on Islote Afuera, a small islet off the southern coast of Guadalupe.

After overcoming the dangerous landing, Moran and Lindsay discovered what they regarded as the most interesting plant on the island, a species of Dudleya.

[6] Chromosome counts of the plants collected by Reid Moran on Islote Afuera and Islote Negro done by Dr. Charles H. Uhl indicate that all collections of the plant are diploid relative to the basic number for the genus, with a chromosome count of n = 17.

The type specimen originates from Islote Afuera (Outer Islet), collected by Reid Moran.

On Islote Negro, plants have both green and farinose foliage, with the rosettes being less clustered and more solitary.

[3] Reid Moran also notes that plants in the nursery trade labeled as D. guadalupensis are in fact D. greenei, a species native to the Channel Islands of California with a different chromosome count.

Moran found that none of the collectors of the cultivated specimens could verify that the source was from Guadalupe Island.