Duilio Arigoni (6 December 1928 – 10 June 2020) was a Swiss chemist and Emeritus Professor at ETH Zurich.

[1] Born in Lugano, Switzerland, Arigoni completed his undergraduate studies in chemistry at the ETH Zürich in 1951.

His major contributions are in the stereochemistry of enzyme-catalyzed reactions and in the biosynthesis of terpenes, alkaloids, and enzyme cofactors.

[2] His strategy of penetrating into the structure of enzyme-substrate interactions by concentrating on the detailed stereochemical fate of isotopic substrate labels, led him to make basic contributions to the mechanism of enzymic reactions requiring coenzyme B12, one of the 'pigments of life'.

In 1989, he was awarded the Wolf Prize in Chemistry along with Alan R. Battersby of the University of Cambridge "for their fundamental contributions to the elucidation of the mechanism of enzymic reactions and of the biosynthesis of natural products, in particular the pigments of life".