The construction of Duke-NUS Medical School's primary facility, the Khoo Teck Puat Building, started in December 2006.

The 13-storey green-certified building was officially inaugurated by Prime Minister of Singapore Lee Hsien Loong on 28 September 2009.

The faculty act as facilitators for student discussions, moving away from traditional pedagogical teaching.

Applicants are also evaluated based on their academic performance, research experience, and evidence of leadership capabilities.

Through this partnership in academic medicine, the AMC harnesses the collective strengths of Duke-NUS' medical education and research capabilities, and SingHealth's clinical expertise to bring about improved healthcare and patient outcomes.

[17] cPass is a COVID-19 test kit that Duke-NUS co-developed with biotech company GenScript Biotech Corporation and the Agency for Science, Technology and Research's (A*Star) Diagnostics Development Hub (DxD Hub), capable of checking for signs of a COVID-19 infection in individuals within an hour.

[20] A precursor of the test was also used to detect Singapore's largest coronavirus infection cluster at the Grace Assembly of God Church.

[22] Co-developed by SingHealth Duke-NUS Academic Medical Centre and the National University of Singapore researchers, this saliva-based COVID-19 Antigen Rapid Test (ART) technology uses a proprietary on-kit amplification technique, enabling detection of the SARS-CoV-2 virus with sensitivity close to that of laboratory-based polymerase chain reaction (PCR) tests, in 15 minutes.