Gustav Wilhelm was born in Ludwigslust on 31 January 1781, the second surviving son of Frederick Francis, Hereditary Prince of Mecklenburg-Schwerin, later Grand Duke, and Princess Louise of Saxe-Gotha-Altenburg.

He was on his Grand Tour in Naples in 1813 when the German campaign of 1813 broke out and subsequently returned to Ludwigslust to take up the rank of major in the Mecklenburger volunteer regiment.

In 1830, he commissioned the architect Friedrich Georg Erich Groß to build Villa Gustava, a residence in Ludwigslust completed in 1832.

Gustav Wilhelm was a talented musician and sang and played guitar at court concerts at Ludwigslust Palace.

[6] Villa Gustava continued to be occupied by members of the grand ducal family, including Duke William and Duchess Paul Frederick, until 1923.