He collaborated with several Italian and American rappers, including Snoop Dogg, Kool G Rap, Lil Ortega, Onyx, Club Dogo, Fabri Fibra, Wu-Tang Clan, Coolio, and Ice-T.[1] He is the father of the Multi-Platinum producer Sick Luke.

He also collaborated with important members of the American rap scene including Onyx, Ice-T, Wu-Tang Clan and starred in the film Le amiche del cuore, directed by Michele Placido, playing the role of himself.

In 2008 Duke Montana took part in the album Ministero dell'Inferno (2010), including collaborations with Italian rappers such as Club Dogo, Marracash, Fabri Fibra, and Noyz Narcos.

It included collaboration with the American hip-hop group Onyx ("Bloodsport"), Club Dogo ("Carta Viola"), Fabri Fibra ("Alphabet Killers"), and other mainstream and underground rappers.

On 15 July 2012, Montana opened the first and the only Italian date of the American rapper Wiz Khalifa, in Milan, together with Fedez.