Duke Nukem, working for general Graves, is asked to investigate Area 51, after reports indicate the hostile infiltration of an alien species.

While in Egypt, Duke Nukem discovers a vast collection of alien hybrid creatures in stasis, apparently an army meant to take over the world.

Subsequently, he learns that activating an override pump will drain the hibernation tanks, killing the entire alien hybrid army.

After transmitting all the data from the ship he can find, Graves tells him they have detected four human females on board which Duke must once again rescue.

He finds the first one and teleports her back to Earth, and after analysis, the general learns that she is in fact a cloned version of their undercover agent, Jenny.

By the time Duke has rescued the Jenny's clones one by one, his general friend informs him that he can destroy the ship by shutting down its engine's coolant system.

"[2] Frank Provo of GameSpot said: "On the basis of technical merit, Duke Nukem Advance is nowhere near as pretty or diverse as the original 1996 PC game, but it's easily the best FPS to hit the GBA since Doom.