This was in a similar set-up as Cornell University's West Campus built a decade prior.

[2] In 1924, Horace Trumbauer's firm was commissioned to build a new campus for Duke University.

This rendering included the Duke Chapel (one of the tallest university chapels in the world),[3] the first four housing quadrangles (now Craven, Crowell, Few, and, Kilgo), the library (now Perkin's Library), Student Union (now the Richard H. Brodhead Center), and departmental buildings.

[8] In July 1939, the Board of Trustees approved the first expansion to the original West Campus, adding the Few Quadrangle, houses FF, GG, and HH.

After additional space for the department was completed, the university remodeled the building in 2015 to reconfigure the building to serve as a maker space[11] and the headquarters for Duke's Social Science Research Institute, part of the Economics Department.

In 2007, Bill and Melinda Gates (an alum of Duke) opened the French Family Science Center, a facility consisting of biological and genetic laboratories.

Duke consists of several undergraduate "Selective Living Groups" (SLGs), which operate as an alternative to Greek Life.

[28] As of 2023, the options for Duke SLGs include Wayne Manor, Brownstone, Maxwell, The Cube, LangDorm, Round Table, Mundi, and JAM!.