The related title of Duke of Newcastle-under-Lyne [sic][2] was created once in the Peerage of Great Britain.

It was conferred in 1756 on Thomas Pelham-Holles, 1st Duke of Newcastle upon Tyne (of the third creation), to provide a slightly more remote special remainder.

The title became extinct in 1988, a year that saw the deaths of the distantly related ninth and tenth Dukes of Newcastle-under-Lyne.

The second Duke's third daughter, Lady Margaret Cavendish (1661-1717), married John Holles, 4th Earl of Clare, who was incidentally her first cousin, her mother's sister's son.

He was succeeded by his son, the aforementioned fourth Earl of Clare, who married a daughter of the second Duke of Newcastle.

In 1694, three years after the title became extinct, the Dukedom of Newcastle was revived and granted to the late Duke's son-in-law.

The following year, the dukedom was revived when he was made Marquess of Clare and Duke of Newcastle upon Tyne, with like special remainder.