The series features the voices of Poehler, Ty Burrell, Riki Lindhome, Zach Cherry, Yassir Lester, Betsy Sodaro, Rashida Jones, Joy Osmanski, and Wiz Khalifa.

Other recurring characters include Mr Mitch, a teacher at the school that works a series of other jobs; Duncan's friends, Yangzi, Bex, and Wolf; the Harris' neighbor, Helen Diggins; Jack's mean-spirited father Dick; and Annie's con-man brother, Stan Theman.

[4][38] On October 26, 2018, it was announced that the network had ordered a 13-episode series, with featured voices Poehler, Rashida Jones, and Wiz Khalifa.

The hour-long program featured interviews with guests and live interactivity with fans online, with recaps for the episodes that aired through April and May.

On November 24, 2019, NBCUniversal Global Distribution announced the series was picked up for broadcast in Australia on the Nine Network and debuted on June 4, 2020 on 9Go!.

The website's critics consensus reads, "Amy Poehler lends her buoyant pipes to dual roles in Duncanville, a modest animated comedy that gets a lot of mileage out of its colorful palette and daydream flourishes.

[67] Robyn Bahr of The Hollywood Reporter praised the series for its humor, stating it contains smart joke-telling and manages to be pleasant, and complimented the performances of the voice actors, while calling the main character nondescript, stating, "Duncanville is another family-friendly comedy that seems about as connected to today's youth as its Groupon jokes seem relevant to 2020.

Club gave "Pilot" a B, found the series funny and entertaining, praised Poehler's charm and the family dynamics of the show, but criticized the main character's lack of interesting motivation.

[69] Ben Travers of IndieWire gave the show's first two episodes a B− grade, stated Duncanville has potential despite being a sitcom about a white working-class family, writing, "Filled with good ideas, appealing designs, and a strong cast, the half-hour comedy has enough potential to warrant keeping track of, while we wait to see how its rounded edges are sharpened into a singular vision.

"[70] Melissa Camacho of Common Sense Media rated the series 3 out of 5 stars, writing, "Duncanville is an animated sitcom about an average teenager living life with his family and friends.