Dune: Prophecy is an American science fiction television series developed by Diane Ademu-John and Alison Schapker for HBO.

Sisters Valya and Tula Harkonnen struggle to maintain the power and influence of the Sisterhood, and combat forces that threaten the future of humanity.

The story sheds light on the origins of the Sisterhood (later known as Bene Gesserit), their rise to power and influence in the Imperium, as well as their personal struggles, conflicts, and battle against a prophesied enemy (the Reckoning / 'Tiran-Arafel'); while at the same time delving into key historical aspects of the Dune universe, such as the roots of the Harkonnen and Atreides families.

[24][25] Legendary eventually contacted Denis Villeneuve to direct a two-part film adaptation of the novel by the next month, and was confirmed as director by February 2017.

[26][27] Legendary Television announced a full series order of Dune: The Sisterhood in June 2019, produced for WarnerMedia's then-streaming service HBO Max.

[41][42] As production of Dune: Part Two progressed, Villeneuve was no longer able to direct and was replaced by Johan Renck as director for the first two episodes in April 2022.

[43] Shortly after production began, Diane Ademu-John had exited the project as co-showrunner but remained the executive producer; this left Alison Schapker as the sole showrunner.

[1] In October 2022, Emily Watson, Shirley Henderson, Indira Varma, Sarah-Sofie Boussnina, Shalom Brune-Franklin, Faoileann Cunningham, Aoife Hinds, and Chloe Lea were cast to star in the series.

[4] The younger versions of Tula, Francesca and Kasha are portrayed by Emma Canning, Charithra Chandran and Yerin Ha, respectively.

[50] It began production on November 22, 2022, under the working title Dune: The Sisterhood, with Renck confirming the start on his Instagram account.

[51][52] In July 2023, Deadline Hollywood reported that, following a winter hiatus, production was set to resume in Budapest amidst the WGA and SAG strikes due to the series' talent working under the UK-based union Equity.

The website's critics consensus reads, "Grounded by reliably terrific performances from Emily Watson and Olivia Williams, Dune: Prophecy lacks the spice of Denis Villeneuve's films but compensates with addictively perilous palace intrigue.