[2] The club's present home, a Romanesque structure designed by Longfellow, Alden & Harlow on Sixth Avenue in downtown Pittsburgh, was opened in 1890; an addition designed by Janssen & Cocken that included a garden patio, barbershop, and new kitchens was constructed in 1931.

[2] The Club voted to admit women for the first time in its history in 1980.

[2][3] Among notable guests to the club are U.S. Presidents Ulysses S. Grant, Herbert Hoover, Gerald Ford,[4] Ronald Reagan,[5][failed verification] George H. W. Bush and Bill Clinton as well as Colin Powell, Polish leader Edward Gierek,[6] Jungle James, Tars Cornish, Gene Simmons, King Charles III (while he was Prince of Wales) and former Pakistan Prime Minister Benazir Bhutto.

[7] Oil businessman and millionaire Philip M. Shannon owned an apartment in the club and died there in 1915.

[8] As of 2007, membership at the Duquesne Club consisted of about 2,700 men and women.