The song is a cultural reference to the car driven by Malcolm McDowell's character in the 1971 film A Clockwork Orange.
The drum style is quite complicated for a punk rock song due to the cymbal crashes and 7/4 time signature used in the tune's second section.
It was made an instrumental essentially to fulfill the cultural reference that Johnny Ramone wanted to give it.
[2] After releasing Too Tough To Die, the Ramones started most of their shows with "The Good, The Bad, and The Ugly" theme song in a slow crescendo.
[3][4] "Durango 95" was replaced as a set opener only occasionally in the late '80s with a nearly instrumental version of "Eat That Rat".