On average, about 161 rail passengers board or detrain daily at Durham, making it the third-busiest Amtrak stop in New Hampshire.

There is a Wildcat Transit and UNH Campus Connector bus stop approximately 1,000 feet (300 m) from the platform on Main Street.

The Boston and Maine Railroad (B&M) began service to Durham in 1841, and by the end of the 19th century included 7 to 12 trains per day.

[6][7] On January 4, 1965, the railroad discontinued all service outside Massachusetts except for single round trips to Concord and Dover, the latter of which served Durham.

[8] The depot was maintained as a restaurant and renovated in 2007-2008 by the university with funding assistance from the United States Department of Transportation.