They are famous for the sample-based music they produced in the 1980s and 1990s,[4] and specifically for their work on the albums Paul's Boutique by the Beastie Boys, Odelay, Midnite Vultures and Guero by Beck, the soundtrack to the film Fight Club, and "MMMBop" by Hanson.
Simpson and John "Gizmo" King started working together as the Dust Brothers in 1985 at Pomona College radio station, KSPC, hosting a weekly hip-hop show called The Big Beat Showcase.
In 1995 the Dust Brothers co-produced Mötley Crüe frontman Vince Neil's second solo album Carved in Stone.
for the Spawn soundtrack; produced the number one hit "MMMBop" for Hanson's first major label album Middle of Nowhere; and created a song on the #1 soundtrack to the Howard Stern film Private Parts named "Tortured Man", featuring vocals by Stern.
The same year also saw the Dust Brothers collaborate with Jeymes Samuel aka the Bullitts on the soundtrack for the film Muppets from Space, recording a cover version of the Earth, Wind & Fire song "Shining Star".