In his first professional bout at the DeSoto Civic Center in Southaven, Mississippi, Dusty faced Alphonso Alexander, a man more than twice his age.
[18] On December 10, 2011, Dusty made his highly anticipated Washington, D.C. debut, fighting on the Amir Khan vs. Lamont Peterson undercard on an HBO World Championship Boxing broadcast.
[24] On February 8, 2013, Dusty scored a third-round stoppage win over former National Golden Gloves Champion Kelly Wright in Wilmington, Delaware.
[28] On May 18, 2013, before a raucous hometown crowd of 3,000 fans that included Wale, Pierre Garçon, and Ty Lawson at the University of the District of Columbia, Dusty faced his toughest opponent to date, Eddie Soto (12–6), in a scheduled eight-round bout.
[31] A little over a month later on June 29, he defeated former WBO Africa Champion Ben Ankrah by unanimous decision on the Gennady Golovkin vs. Matthew Macklin undercard.
Dusty remained in control and the referee stopped the bout in the fourth round following a vicious barrage of punches along the ropes, bringing the crowd to its feet for their new "hometown" star.
He earned the belt by defeating Josh "Pit Bull" Torres (12–2–1) via ten-round unanimous decision on the Gennady Golovkin vs. Curtis Stevens undercard.
His father Buddy Harrison recalled his son's hard work and dedication following the WBC Youth Silver Welterweight World Championship fight: "I told Dusty nearly ten years ago in this very arena that if he worked hard and did the right things he could one day win a world title at Madison Square Garden.
"[35] Dusty has a "close-knit professional team" that includes his father and trainer, Buddy, cut-man Billy Briscoe, and matchmaker Mike Walters.
Always making sure to recognize their continued support, at the Nov. 2 WBC Youth Silver World Championship Bout, Dusty noted, "It is really hard to put into words how much it means to me that my fans could share this special moment with me," as he greeted each one personally on the chartered buses of fans that made the trip from Washington, D.C. to support Dusty.
"[39] Five weeks later on March 7, 2014, Dusty was once again on ESPN Friday Night Fights, earning a hard-fought unanimous decision victory over Michael Balasi (10–3, 7 KOs), a hard-hitting southpaw.
[40] On May 17, 2014, on his first trip to West Virginia, Dusty dominated the dangerous Roberto Valenzuela, owner of 56 KOs, en route to a fourth-round TKO.
[41] On July 26, 2014, Dusty got his first taste of the big room at Madison Square Garden as he won a shutout unanimous decision over another hard-hitting southpaw in Wifredo Acuna on the Gennady Golovkin vs. Daniel Geale undercard.
[46] Among the star-studded crowd of 4,253 at The Theater at Madison Square Garden were Jay Z, Rihanna, CC Sabathia, Jake Gyllenhaal, Rosie Perez, Carmelo Anthony, Victor Cruz, Andre Ward, Big Sean, Fabolous, Michael K. Williams, Bryant Jennings, Angie Martinez, DJ Mustard, Sam Dew, Santigold, Melanie Fiona, and Wardell.
[49][50] On April 17, 2015, at the Foxwoods Resort Casino, Dusty earned a shutout unanimous decision win over durable veteran Chris Gray.
[52] A little over a month later on September 26 in Norfolk, Virginia, against veteran James Wayka, Dusty scored the fastest knockout of his career,[citation needed] as it only took him 78 seconds to dispatch his opposition.
Dusty spent five weeks leading up to the fight with Dallas in San Diego as a sparring partner for Mexican superstar Canelo Álvarez.
[58] In Dusty's biggest fight, which took place on September 15, 2016, at the 2300 Arena in Philadelphia on CBS Sports Network, he won a unanimous decision over Thomas LaManna (21–1) by scores of 98–92 and 97–93 (x2) to win the vacant USBA welterweight title and earn himself a top 15 world ranking by the International Boxing Federation.
[62] Dusty made his highly anticipated return to the ring after nearly three years on March 30, 2019, against Bruce Rumbolz at the Grand Theater in New Albany, Indiana.
Dusty would put on the pressure in the fourth round and landed a four-punch combo that would drop Jenkins Jr. to the canvas, who was counted out at the 2:17 mark.
[64] On July 19 at the MGM National Harbor in Oxon Hill, Maryland, Dusty stopped Colombian fighter Juan De Angel in the seventh round.
He beat the referee's count, but spit his mouthpiece out, indicating he did not want to continue and the ref waived the fight off at the 2:30 mark, much to the delight of Dusty's large contingent of fans who made the short trip from D.C.[65][66] Asked about his plans now that he’s back in the ring and active, Harrison said, "Mentally, I’m in the best place I’ve ever been.
[69] Dusty returned to the ring after a three-and-a-half-year layoff on September 15, 2023 to face Colombian veteran boxer Ronald Montes in Richmond, Virginia.