She participated in the siege of Acre in 1799 with the result that her crew qualified for the Naval General Service Medal issued in 1847.

In May, the Batavian Republic signed a peace and alliance treaty with France and the French returned Alliantie against payment.

At 16:15 the leading British ship, Stag, under Captain Joseph Sydney Yorke, caught and engaged the rearmost Batavian ship, Alliante; the remainder of the British squadron continued in pursuit of the Batavian squadron.

The remainder of the Batavian squadron escaped due to a fierce rearguard action by the frigate Argo, safely reaching Eigerøya.

[5] Alliante was subsequently taken to Spithead where the Admiralty purchased her for the Royal Navy as the frigate HMS Alliance.

Troubridge and his squadron left Acre for Alexandria, with Sir Sidney Smith in Tigre replacing them.

On 24 March, Alliance arrived at Acre with orders from Troubridge to discharge her cargo and return immediately.

[9] Smith anchored Tigre and HMS Theseus, one on each side of the town, so their broadsides could assist the defence.

On 21 May he destroyed his siege train and retreated back to Egypt, having lost 2,200 men dead, 1,000 of them to the plague.