Brederode was a ship of the line of the Maas Admiralty, part of the navy of the United Provinces of the Netherlands, and the flagship of the Dutch fleet in the First Anglo-Dutch War.

[1] Launched at Rotterdam in 1644, and a design of shipwright Jan Salomonszoon van den Tempel, she was the flagship of Vice-Admiral Witte Corneliszoon de With from May 1645 until 1647 when she was assigned to Lieutenant-Admiral Maarten Tromp.

De With delegated actual command of the vessel to Lieutenant Jan Janszoon Quack, who remained in that role after the expedition returned to Holland in 1647.

With Tromp back in command, Brederode fought at the Battle of Dungeness on 10 December 1652 where she came close to being captured, but was instrumental in that victory over the English.

The acting flag captain (later Admiral) Egbert Bartholomeusz Kortenaer kept Tromp's standard raised after his death to keep up morale.

Van Wassenaer's flagship was Eendracht; De With commanded the van in Brederode; attacking the enemy without proper knowledge of the shoals he grounded his ship (after damaging Leoparden so much that this enemy vessel subsequently was lost by fire) and was surrounded; after many hours of fighting, Brederode was boarded by Wismar and De With mortally wounded.