[2][3] Dyersburg was chosen by the Tennessee State Board of Education in 1967 as the location for the second community college in western Tennessee as part of the state's response to the 1957 Pierce-Albright report to the state's Legislative Council, which led to a plan to place a postsecondary institution within a 30-50 mile of each Tennessee resident.

[5] At its September 2022 board meeting, the Tennessee Board or Regents approved a change in Dyersburg State Community College’s service area, adding Crockett, Haywood, Henry, and Weakley Counties, effective July 1, 2023.

As a result, the Gibson County Center in Trenton, TN, was transferred to Jackson State Community College and Dyersburg State’s Henry County Center in Paris opened July 1.

Classes are held on the 100-acre campus in Dyersburg and at centers in Covington and Paris.

Dyersburg State Community College serves nine counties adjacent to or near the Mississippi River in West Tennessee.