Dyke River is a perennial stream of the Macleay River catchment, located in the Northern Tablelands district of New South Wales, Australia.

Dyke River rises on the southern slopes of the Cunnawarra Range on the Dorrigo Plateau in high country east of Uralla and west of Nambucca Heads, and flows generally south by west before reaching its confluence with the Macleay River at Lower Creek, west of Comara.

The river descends 1,050 metres (3,440 ft) over its 28 kilometres (17 mi) course.

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