He began his career as a child actor and received recognition for his role as a younger version of the character Michael Scofield on the drama series Prison Break (2005–2006).

Minnette had a starring role in the horror comedy Goosebumps (2015), and gained wider recognition for portraying Clay Jensen in the Netflix drama series 13 Reasons Why (2017–2020).

[7] In the following year, Minnette co-starred in the film Goosebumps, based on the R. L. Stine's children's horror book series of the same name.

[12] From 2017, Minnette began starring in the Netflix teen drama television series 13 Reasons Why, an adaptation of the 2007 novel of the same name, as Clay Jensen.

[13][14] His portrayal won him critical praise; The Hollywood Reporter wrote: "Minnette is so dedicated to playing despondent that the relief and pleasure in brief scenes of flirty banter between Hannah and Clay is palpable".

[17][18] In September 2020, Minnette was cast as Wes Hicks in the fifth Scream film, which was directed by Matt Bettinelli-Olpin and Tyler Gillett.

They performed at Summer Meltdown, a concert for autism awareness in 2010[27] and won a battle of the bands contest the same year, sponsored by 98.7 FM.

[28] They played at Vans Warped Tour 2011[29] and have since performed at many Los Angeles venues including the Roxy Theatre and Whisky a Go Go.

[37] Minnette performed with Wallows at Coachella 2022 which was headlined by Harry Styles, Billie Eilish and The Weeknd x Swedish House Mafia.