Investigations may be performed to identify underlying disease processes that may have led to the development of symptoms or autonomic neuropathy.

[12] Dysautonomia, a complex set of conditions characterized by autonomic nervous system (ANS) dysfunction, manifests clinically with a diverse array of symptoms of which postural orthostatic tachycardia syndrome (POTS) stands out as the most common.

[11] The symptoms of dysautonomia, which are numerous and vary widely for each person, are due to inefficient or unbalanced efferent signals sent via both systems.

Symptoms typically arise from abnormal responses of either the sympathetic or parasympathetic systems based on situation or environment.

A diagnosis should at a minimum include measurements of blood pressure and heart rate while lying flat and after at least three minutes of standing.

[40] Treatment of dysautonomia can be difficult; since it is made up of many different symptoms, a combination of drug therapies is often required to manage individual symptomatic complaints.

[41] To treat genitourinary autonomic neuropathy, medications may include sildenafil (a guanine monophosphate type-5 phosphodiesterase inhibitor).

[5] Autonomic dysfunction symptoms such as orthostatic hypotension, gastroparesis, and gustatory sweating are more frequently identified in mortalities.