Dyserth is mentioned in the Domesday Book of 1086, listed in the Hundred of Ati's Cross and within Cheshire:[3][4] Ad hoc manerium ROELENT jacent hae berewiches, DISSAREN BODUGAN CHILVEN et MAENEVAL.

One foreign woman and 2 villeins have 1 carucate there.In the Middle Ages, Dyserth was the centre of the commote of Prestatyn, in the cantref of Tegeingl.

According to the antiquary Edward Lhuyd, the poet, scholar and priest Dafydd Ddu o Hiraddug (died around 1370) was buried in Dyserth church.

The oldest industry in the village and surrounding area is mining, with lead, copper and limestone just some of the minerals being extracted locally in the past.

Many of the village's families have their roots in agriculture, with many notable farms in or around Dyserth, including Hottia, Bryn Cnewyllyn and Ty Newydd.

[8] The Dyserth branch line was opened by the London and North Western Railway in 1869 to tap limestone quarries and a lead mine.

[11] Road competition and the 1926 General Strike ate into profits, leading the London, Midland and Scottish Railway to withdraw the passenger service in 1930.