[2] Dytikosicula's affinity is unclear, although it may be allied with the megacheirans like its apparent relative Dicranocaris.

Dytikosicula differs from Dicranocaris by having a pleural extension on its first trunk segment, alongside a somewhat more circular head.

Due to this, material formerly assigned to Dicranocaris from the Wheeler Formation may belong to this genus instead.

This genus also shares similarities with Serracaris from the Kinzers Formation, namely an elongate trunk with large pleurae.

The species name, desmatae, derives from the Greek word desmos meaning "chain", in reference to its proposed link to other Cambrian megacheirans.