[citation needed] He is also the founder and Chairman of Jaiputra College Management Board, Kelantan (1999-2003), the first IPTS fully accredited by the Ministry of Education which conducts an integrated course of professionalism and religion.

He has also written and commented on current issues in the print and electronic media and presents work at national and international levels (economic development, racial relations and clash of Western-Western civilization, Political Islam etc.).

Since his involvement has resulted in several books in English and Bahasa Malaysia such as Blindspot (2003), Striving For Change (2007), Pergelutan Demi Perubahan (2016) and Najibnomiks: Rahmat atau Malapetaka?

He is also active in writing as a columnist in The Edge magazine and media portals such as Malaysiakini, The Malaysian Insight, TMI, Free Malaysia Today.

Internationally and nationally, he is often invited to share his thoughts and experiences in 'Political Islam', the socio-economic development agenda and inter-religious issues and between civilizations.

On the rising cases of the COVID-19 pandemic, he assured the nation that there are enough vaccine supplies and raised the possibility of issuing new instructions on booster doses for high-risk groups as well as mandating masking again.

He also made Electronic medical records (EMR), digitising healthcare, health financing reforms and upgrading dilapidated facilities his priorities during his second term in the position.

Dzulkefly also reviewed guidelines on what to do when a person tests positive for COVID-19 at home, after social media users complained that the Covid-19 Assessment Centre (CAC) hotline set up during the pandemic was no longer working and called on Malaysians with severe symptoms to visit the nearest government health clinic or hospital.

[8] On 18 December 2023, Dzulkefly held the first press conference in his second term to address the pandemic, he dismissed the reintroduction of the Movement Control Order (MCO) and outlined five strategies to bring down the cases.

On 31 December 2021, Dzulkefly Ahmad has filed a defamation suit against former prime minister Najib Razak following his allegations of nepotism and cronyism.

Dzulkefly filed a statement of claim at Kuala Lumpur High Court, providing a 24 August 2020, Facebook post by Najib together with a Sinar Harian article dated 28 January 2019, as key evidence.