It was originally serialized in Monthly GFantasy from 1997 through 2005, and later published in 16 tankōbon volumes by Square Enix from March 18, 2003, to February 27, 2010.

The series focuses on Kai Kudō, an "Esper", who is recruited by an organization called Ashurum to become a soldier to purportedly save other psychics from regular humans.

After a mission in Gald goes wrong, Kai finds himself living with a man named Yuuki and his adopted sister Asuka.

Broccoli Books licensed the manga series for English-language publication in North America in 2006.

After a year, Shen-long warned Kai that Eiji actually only wanted his sister, because she was said to possess amazing psychic powers, but she was not able to use them due to her illness.

However Broccoli International USA closed down at the end of 2008 and stopped all printing in progress and have halted release of new works.

[1] The series is also licensed for regional language releases in German by Carlsen Comics and in Chinese by Tong Li Publishing.

ADV Films also released the series in Germany, with German dubbing provided by Elektrofilm.

[10] Two light novels adaptations of the manga, also written by Yuiga, have been published by Square Enix.

[4][13] E's Zero World Guidance (E'S ワールドガイダンス 零, E'S Waarudo Gaidansu Rei), published by Square Enix in August 2003, is a guidebook containing additional information about the various fictional aspects of the series, characters, etc.