Major exhibitors at the convention included Activision Blizzard, Atlus, Bethesda Softworks,[2] Electronic Arts, Microsoft Studios, Nintendo, Nvidia, Sony Computer Entertainment, Square Enix[3] and Ubisoft.

Microsoft hosted a press conference on June 15 at 9:30 a.m.[9] During the conference, Microsoft announced ReCore, Xbox One backward compatibility, a new Elite controller, Plants vs. Zombies: Garden Warfare 2, Dark Souls III, Ashen, Beyond Eyes, Ion, Rare Replay, Sea of Thieves and Gears of War: Ultimate Edition and showed footage of Halo 5: Guardians, Forza Motorsport 6, Fallout 4 with mod support, Tom Clancy's The Division, Tom Clancy's Rainbow Six Siege, Gigantic, Tacoma, Cuphead, Rise of the Tomb Raider, Fable Legends, a version of Minecraft compatible with Microsoft HoloLens and Gears of War 4.

Sony hosted a press conference on June 15 at 6:00 p.m.[9][12] During the conference, Sony re-announced The Last Guardian, announced a new IP titled Horizon Zero Dawn, Hitman, Dreams, Firewatch, Destiny: The Taken King, Final Fantasy VII Remake, and Shenmue III, in addition to showing footage of No Man's Sky, Assassin's Creed Syndicate, Batman: Arkham Knight, Call of Duty: Black Ops III, Disney Infinity 3.0, Star Wars: Battlefront, Ratchet & Clank and Uncharted 4: A Thief's End.

[14][15] During the Digital Event, Nintendo announced Star Fox Zero, amiibo figures compatible with Skylanders: SuperChargers, The Legend of Zelda: Tri Force Heroes, Hyrule Warriors Legends, Metroid Prime: Federation Force, Fire Emblem Fates, Tokyo Mirage Sessions ♯FE, showed footage of Xenoblade Chronicles X, announced Animal Crossing: Happy Home Designer, Animal Crossing: amiibo Festival, showed footage of Yoshi's Woolly World, announced Yo-kai Watch, Mario & Luigi: Paper Jam, Mario Tennis: Ultra Smash and showed footage of Super Mario Maker.

Square Enix hosted a press conference on June 16 at 10:00 a.m.[9] During the conference, Square Enix announced Nier: Automata under the provisional title Nier New Project, Lara Croft Go, Kingdom Hearts Unchained χ, Star Ocean: Integrity and Faithlessness and a new IP titled I Am Setsuna and showed footage of Just Cause 3, Rise of the Tomb Raider, Kingdom Hearts III, World of Final Fantasy, Hitman and Deus Ex: Mankind Divided.