The EMD GP38-2 is an American four-axle diesel-electric locomotive built by General Motors, Electro-Motive Division.

Power is provided by an EMD 645E 16-cylinder engine, which generates 2,000 horsepower (1.5 MW).

Although a W is commonly suffixed to the name, it is actually an addition by enthusiasts to help specify the presence of a CN-spec comfort cab.

A total of 51 GP38-2s were built with high-short-hoods containing steam generators for passenger service on Mexican railways.

A number of higher horsepower 40 Series locomotives have been rebuilt into the equivalent of a GP38-2, by removal of the turbocharger and the substitution of twin Roots blowers.

CSX and Norfolk Southern have both started replacing cabs on the aging locomotives.