The SD45T-2 is a model of diesel-electric locomotive built by EMD for the Southern Pacific Railroad.

The SD45T-2 is a variant of the venerable SD45 that featured the "Dash 2" upgrade components such as improved electronics and high traction trucks, with the "T" denoting its cooling system modifications.

Tunnel motors were built for mountainous areas in the western United States, where SP had previously encountered repeated overheating issues on their SD45s.

Another spotting difference is the SD45T-2's three fan access doors on each side above the cooling air intake, while the SD40T-2 has two.

Like their SD40T-2, some of SP's SD45T-2 tunnel motors were obtained by Kansas City Southern Railway, Bessemer and Lake Erie Railroad, Duluth, Missabe and Iron Range Railway, and by the Union Pacific Railroad when it merged the SP in 1996.